Articles

"Disease-modification" trials in Parkinson disease: target populations, endpoints and study design

However, presently, no fully satisfying efficacy "disease-modification" study design exists, and no drug has yet been approved for that indication....

A positive correlation between fractional white matter volume and the response of Parkinson disease patients to subthalamic stimulation

Using preoperative magnetic resonance imaging studies of 21 Parkinson’s disease (PD) patients treated by STN stimulation, the authors performed...

A wearable system to assist walking of Parkinson's disease patients

The authors developed a real-time wearable FOG detection system that automatically provides a cueing sound when FOG is detected, with the sound...

Assessing the effects of subthalamic nucleus stimulation on gait and mobility in people with Parkinson disease

Gait and mobility were therefore able to be assessed in the medication-on state at three time points: prior to surgery, after the first surgery...

Asymptomatic deep venous thrombosis after deep brain stimulation for Parkinson disease

41 consecutive PD patients undergoing stereotactic surgery for STN-DBS were investigated; ultrasonographic examinations demonstrated that two...

Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial

The study showed that in patients with advanced PD, deep brain stimulation was more effective than best medical therapy in improving on time without...

Cannabinoids and Parkinson's disease

Cannabinoid-based medicines have been proposed as clinically promising therapies for the treatment of PD. Supporting this pharmacological potential,...

Challenges in the Long-term Evolution of Parkinson’s Disease

There is a change in the clinical manifestation of Parkinson's disease (PD) over time. Figure 1 provides a schematic overview of this process, ...

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